QMUL's High-Performance Computing Cluster, Apocrita, enables research across all academic disciplines in the university. Below are a few examples of recent research outputs that have utilised the facility, demonstrating the wide variety of work undertaken. The facility is supported by the ITS Research group at QMUL.
Exploiting Class Labels to Boost Performance on Embedding-based Text Classification
"Text classification is one of the most frequent tasks for processing textual data, facilitating among others research from large-scale datasets. Embeddings of different kinds have recently become the de facto standard as features used for text classification. These embeddings have the capacity to capture meanings of words inferred from occurrences in large external collections". Read More
Analysis of the atomic structure of CdS magic-size clusters by X-ray absorption spectroscopy†
"Magic-size clusters are ultra-small colloidal semiconductor systems that are intensively studied due to their monodisperse nature and sharp UV-vis absorption peak compared with regular quantum dots. However, the small size of such clusters (<2 nm), and the large surface-to-bulk ratio significantly limit characterisation techniques that can be utilised. Here we demonstrate how a combination of EXAFS and XANES analyses can be used to obtain information about sample stoichiometry and cluster symmetry." Read More
Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia
"Acute myeloid leukemia (AML) is characterised by a series of genetic and epigenetic alterations that result in deregulation of transcriptional networks. One understudied source of transcriptional regulators are transposable elements (TEs), whose aberrant usage could contribute to oncogenic transcriptional circuits. However, the regulatory influence of TEs and their links to AML pathogenesis remain unexplored." Read More
Rolling Horizon NEAT for General Video Game Playing
"This paper presents a new Statistical Forward Planning (SFP) method, Rolling Horizon NeuroEvolution of Augmenting Topologies (rhNEAT). Unlike traditional Rolling Horizon Evolution, where an evolutionary algorithm is in charge of evolving a sequence of actions, rhNEAT evolves weights and connections of a neural network in real-time, planning several steps ahead before returning an action to execute in the game. Different versions of the algorithm are explored in a collection of 20 GVGAI games, and compared with other SFP methods and state of the art results. Although results are overall not better than other SFP methods, the nature of rhNEAT to adapt to changing game features has allowed to establish new state of the art records in games that other methods have traditionally struggled with. The algorithm proposed here is general and introduces a new way of representing information within rolling horizon evolution techniques. " Read More
Simplicial complexes: higher-order spectral dimension and dynamics
"Simplicial complexes constitute the underlying topology of interacting complex systems including among the others brain and social interaction networks. They are generalized network structures that allow to go beyond the framework of pairwise interactions and to capture the many-body interactions between two or more nodes strongly affecting dynamical processes. In fact, the simplicial complexes topology allows to assign a dynamical variable not only to the nodes of the interacting complex systems but also to links, triangles, and so on. " Read More
EVOLUTIONARY COMPUTATION IN COMBINATORIAL OPTIMIZATION: 20th European
"This book constitutes the refereed proceedings of the 20th European Conference on Evolutionary Computation in Combinatorial Optimization, EvoCOP 2020, held as part of Evo*2020, in Seville, Spain, in April 2020, co-located with the Evo*2020 events EuroGP, EvoMUSART and EvoApplications. The 14 full papers presented in this book were carefully reviewed and selected from 37 submissions. The papers cover a wide spectrum of topics, ranging from the foundations of evolutionary computation algorithms and other search heuristics, to their accurate design and application to combinatorial optimization problems." Read More
Peter Pan Discs: finding Neverland’s parameters
"Peter Pan discs are a recently discovered class of long-lived discs around low-mass stars that survive for an order of magnitude longer than typical discs. In this paper we use disc evolutionary models to determine the required balance between initial conditions and the magnitude of dispersal processes for Peter Pan discs to be primordial." Read More
Genomic basis of European ash tree resistance to ash dieback fungus
"Scientists say there is new hope in the fight against a disease that is devastating ash trees. A study has identified the genes that give trees resistance to ash dieback, which arrived in the UK in 2012 and has now spread to almost every part of the country. The discovery suggests that trees could now be bred that are unaffected by the epidemic. The research is published in the journal Nature Ecology and Evolution." Read More on BBC News
Cardiovascular Predictive Value and Genetic Basis of Ventricular Repolarization Dynamics
"Early prediction of cardiovascular risk in the general population remains an important issue. The T-wave morphology restitution (TMR), an ECG marker quantifying ventricular repolarization dynamics, is strongly associated with cardiovascular mortality in patients with heart failure. Our aim was to evaluate the cardiovascular prognostic value of TMR in a UK middle-aged population and identify any genetic contribution." Read More
Understanding Aggregation Induced Emission in a Propeller‐Shaped Blue Emitter.
"Organic fluorophores with an enhanced emission in the condensed phase have great potential for the design of optoelectronic materials. Several propeller‐shaped molecules show aggregation‐induced emission (AIE), in particular, silole derivatives have attracted wide attention because of their significant quantum yields in the solid state." Read more
The full dynamics of energy relaxation in large organic molecules: from photo-excitation to solvent heating.
"In some molecular systems, such as nucleobases, polyenes or the active ingredients of sunscreens, substantial amounts of photo-excitation energy are dissipated on a sub-picosecond time scale, raising questions such as: where does this energy go or among which degrees of freedom it is being distributed at such early times? Here we use transient absorption spectroscopy to track excitation energy dispersing from the optically accessible vibronic subsystem into the remaining vibrational subsystem of the solute and solvent. Monitoring the flow of energy during vibrational redistribution enables quantification of local molecular heating". Read more
Tax evasion as contingent debt.
"This paper studies income-tax evasion in a quantitative incomplete-markets setting with heterogeneous agents. A central aspect is that, realistically, evaded taxes are a form of contingent debt. Since evasion becomes part of a portfolio decision, risk and credit considerations play a central part in shaping it. The model calibrated to match estimated average levels of evasion does a good job in producing observed cross-sectional average evasion rates that decline with age and with earnings.” Read more
Deep learning the high variability and randomness inside multimode fibres.
"This research utilised Queen Mary's Apocrita HPC facility to train our network’s models. The training phase of the network was performed under the Linux Singularity container using a Tesla K80 GPU card (Nvidia) and a 16 Core Xeon E5-2683V3 processor (Intel) with 7.5GB RAM requested for each core.” Read more
Phenotypically distinct female casts in honey bees are defined by alternative chromatin states during larval development.
“The capacity of the honey bee to produce three phenotypically distinct organisms (two female castes; queens and sterile workers, and haploid male drones) from one genotype represents one of the most remarkable examples of developmental plasticity in any phylum. the queen–worker morphological and reproductive divide is environmentally controlled during post-embryonic development by differential feeding.” Read more
Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species.
“Mammalian species exhibit a wide range of lifespans. To date, a robust and dynamic molecular readout of these lifespan differences has not yet been identified. Recent studies have established the existence of ageing-associated differentially methylated positions (aDMPs) in human and mouse.” Read More
European Commission reverses decision on drug, following QMUL research.
A drug for multiple sclerosis (MS) has been granted a license by the European Commission, following evidence from Queen Mary University of London (QMUL) that it improves patients’ quality of life and is safer than previously thought. Read more